PRIMROSE: Evaluating interventions to reduce cardiovascular disease risk in people living with severe mental illness


People living with severe mental illness experience profound healthcare inequalities and have a reduced life expectancy of 10-20 years, particularly from cardiovascular disease (CVD), due to excess modifiable risk factors.

This research project is evaluating PRIMROSE-A, an adaptation of an intervention to improve the assessment and management of cardiovascular disease (CVD) risk in people with severe mental illnesses such as bipolar disorder, psychosis and schizophrenia.

This research involves carrying out qualitative interviews with people who used the intervention, those who delivered it, and those who set up and managed it. The primary aim of the study is to explore the experiences of those involved with all aspects of the intervention. The secondary aims are to explore the impact of the COVID-19 pandemic on the delivery of the intervention, and to explore other factors influencing the implementation of the intervention.

The project also been awarded additional funding from the NIHR ARC Multiple Long-Term Conditions Implementation Programme to lead the UCLP PRIMROSE-A evaluation. The UCLP PRIMROSE-A project will demonstrate the impact of combining the UCLPartners Proactive Care frameworks with Primrose-A to provide sustainable targeted physical health interventions and economic efficiencies at scale within the existing workforce, amplify health benefits and reduce health inequalities.

UCLPartner’s Proactive Care frameworks – widely supported both regionally and nationally - can enhance Primrose-A by identifying patients on primary care records with severe mental illness to optimise management.

Learn more about the PRIMROSE-A intervention.

Learn more about UCLPartner's Proactive Care Frameworks.

Partners & Collaborators

NIHR ARC North Thames (ARC NT)

NIHR ARC Yorkshire and Humber (YHARC)

NIHR ARC East Midlands (ARC EM)

Camden & Islington NHS Foundation Trust

Camden CCG


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